Combination therapy targeting cancer metabolism

Targeting glucose metabolism for cancer therapy

Cellular transformation is associated with the reprogramming of cellular pathways that control proliferation, survival, and metabolism. Among the metabolic changes exhibited by tumor cells is an increase in glucose metabolism and glucose dependence. It has been hypothesized that targeting glucose metabolism may provide a selective mechanism by which to kill cancer cells. In this minireview, we ...

Challenges in targeting cancer metabolism for cancer therapy.

A tumour is clonogenic in origin, dividing and accumulating accidental mutations over time to become a complex, heterogeneous mix of cells. By the time it is diagnosed, a typical tumour mass contains 30–80 somatic mutations [1]. This heterogeneity makes it difficult to eliminate all cancerous cells simultaneously by targeting mutated gene products [2], and we believe that even a single cancer c...

Editorial: Cancer Metabolism: Molecular Targeting and Implications for Therapy

Targeting cancer metabolism.

The understanding that oncogenes can have profound effects on cellular metabolism and the discovery of mutations and alterations in several metabolism-related enzymes--isocitrate dehydrogenase 1 (IDH1), isocitrate dehydrogenase 2 (IDH2), succinate dehydrogenase (SDH), fumarate hydratase (FH), and pyruvate kinase M2 (PKM2)--has renewed interest in cancer metabolism and renewed hope of taking the...

Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism

Background: Both mitochondrial dysfunction and aerobic glycolysis are signs of growing aggressive cancer. If altered metabolism of cancer cell is intended, using the glycolysis inhibitor (2-deoxyglucose (2DG)) would be a viable therapeutic method. The AMP-activated protein kinase (AMPK), as a metabolic sensor, could be activated with metformin and it can also launch a p53-dependent metabolic ch...